The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

Chon-Kit Chou^{1

2}, Ya-Ting Yang², Ho-Chun Yang², Shih-Shin Liang^{2

3}, Tsu-Nai Wang^{3

4}, Po-Lin Kuo⁵, Hui-Min David Wang⁶, Eing-Mei Tsai^{7

8

9}, Chien-Chih Chiu^{10

11

12

13

14}

Affiliations

¹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
² Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
³ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁴ Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁵ Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁶ Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 402, Taiwan.
⁷ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
⁸ Headquarters of Research Centers, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
⁹ Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
¹⁰ Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹¹ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹² Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 804, Taiwan. cchiu@kmu.edu.tw.
¹³ Department of Medical Research, Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹⁴ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.

PMID: 29209738
DOI: 10.1007/s00005-017-0494-2

Review

The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

Chon-Kit Chou et al. Arch Immunol Ther Exp (Warsz). 2018 Jun.

. 2018 Jun;66(3):183-197.

doi: 10.1007/s00005-017-0494-2. Epub 2017 Dec 5.

Authors

Chon-Kit Chou^{1

2}, Ya-Ting Yang², Ho-Chun Yang², Shih-Shin Liang^{2

3}, Tsu-Nai Wang^{3

4}, Po-Lin Kuo⁵, Hui-Min David Wang⁶, Eing-Mei Tsai^{7

8

9}, Chien-Chih Chiu^{10

11

12

13

14}

Affiliations

¹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
² Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
³ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁴ Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁵ Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁶ Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 402, Taiwan.
⁷ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
⁸ Headquarters of Research Centers, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
⁹ Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
¹⁰ Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹¹ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹² Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 804, Taiwan. cchiu@kmu.edu.tw.
¹³ Department of Medical Research, Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹⁴ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.

PMID: 29209738
DOI: 10.1007/s00005-017-0494-2

Abstract

Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner. In this review, we comprehensively summarize the accumulated literature regarding the multifaceted roles of DEHP in the activation of the nuclear receptors, the alteration of the redox homeostasis, epigenetic modifications and the acquisition of chemoresistance.

Keywords: Chemoresistance; DEHP; Epigenetic modifications; Nuclear receptors; Redox homeostasis; Tumorigenesis.

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The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

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The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

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