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. 1989 Feb;81(3):239-42.
doi: 10.1007/BF00278996.

Expression of fragile sites in human sperm and lymphocyte chromosomes

J Benet  1 , C Fuster, A Genescà, J Navarro, R Miró, J Egozcue, C Templado
Affiliations

Expression of fragile sites in human sperm and lymphocyte chromosomes

J Benet et al. Hum Genet. 1989 Feb.

Abstract

Sperm and lymphocyte chromosome studies in a normal, fertile male have shown a high degree of coincidence between chromosome lesions and fragile sites in both types of cells. In this donor we also found that some fragile sites expressed in sperm chromosomes coincided with those expressed in lymphocyte chromosomes. These results indicate that the chromosome lesions expressed in sperm do not occur at random and that they are not technical artifacts. The fragility expression in sperm chromosomes could reflect in vivo conditions. The presence in some sperm metaphases of acentric fragments suggests that chromosome fragility can result in the loss of chromosome fragments or give rise to de novo structural rearrangements. However, the incidence of sperm with chromosomal abnormalities observed in this man was within the normal range.

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References

    1. Cytogenet Cell Genet. 1987;46(1-4):316-24 - PubMed
    1. Cytogenet Cell Genet. 1986;42(1-2):57-61 - PubMed
    1. Science. 1984 Dec 7;226(4679):1199-204 - PubMed
    1. Hum Genet. 1986 Jul;73(3):232-4 - PubMed
    1. J Med Genet. 1986 Jun;23(3):279 - PubMed

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