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Case Reports
. 2018 Feb;45(2):180-183.
doi: 10.1111/cup.13082. Epub 2017 Dec 17.

Genomic analysis of a case of agminated Spitz nevi and congenital-pattern nevi arising in extensive nevus spilus

Caitlin Porubsky  1 , Jamie K Teer  2   3 , Yonghong Zhang  2 , Maria Deschaine  3 , Vernon K Sondak  4 , Jane L Messina  3   4
Affiliations
Case Reports

Genomic analysis of a case of agminated Spitz nevi and congenital-pattern nevi arising in extensive nevus spilus

Caitlin Porubsky et al. J Cutan Pathol. 2018 Feb.

Abstract

Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi. We performed genetic analysis to further characterize the mutational profile of this rare entity.

Keywords: HRAS; Spitz nevus; congenital nevus; genomics; nevus spilus.

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Figures

Figure 1
Figure 1
Extensive macular hyperpigmentation involving right shoulder and arm, studded with varying-sized and -colored papules.
Figure 2
Figure 2
Macular lesion covering left forearm, containing large pink papules and small brown papules. Note hypopigmented region of prior biopsy.
Figure 3
Figure 3
Single arrow denotes an erythematous papule that is characteristic of the patient's desmoplastic Spitz nevi. The double dashed arrow denotes the congenital-pattern compound nevus.
Figure 4
Figure 4
Epidermal hyperplasia overlies a compound nevus composed of oval, uniform Spitzoid melanocytes. Note cellular maturation and prominent stromal desmoplasia in deeper portions of lesion (magnification, 10×).
Figure 5
Figure 5
Spitz nevus dermal component, showing large but uniform oval melanocytes without mitotic activity, surrounded by thick collagen bundles (magnification, 20×).
Figure 6
Figure 6
Congenital-pattern compound nevus, showing dermal component of small nested melanocytes in linear arrays, extending into deep dermis with splaying among collagen bundles (magnification, 4×).
Figure 7
Figure 7
Shared mutations found in nevus spilus, Spitz nevi and congenital nevus.
See this image and copyright information in PMC

References

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