Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Jan 15;124(2):242-244.
doi: 10.1002/cncr.31137. Epub 2017 Dec 6.

"Epigenetic" modification as therapy for acute myeloid leukemia

Charles A Schiffer  1
Affiliations
Editorial

"Epigenetic" modification as therapy for acute myeloid leukemia

Charles A Schiffer. Cancer. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST DISCLOSURES

Charles A. Schiffer reports participation in an advisory board for Celgene and participation in data safety and monitoring boards for Pfizer, Ambit, Astellas, Pharmacyclics, Takeda, and Juno outside the submitted work.

Comment on

References

    1. Roboz GJ, Kantarjian H, Lee KWL, et al. Dose, schedule, safety, and efficacy of guadecitabine in relapsed or refractory acute myeloid leukemia. Cancer. 2018;124:325–334. - PMC - PubMed
    1. Astex Pharmaceuticals. Guadecitabine (SGI-110). http://astx.com/research-development/clinical-pipeline/guadecitabine-sgi.... Accessed October 2017.
    1. Figueroa ME, Lugthart S, Li Y, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 2010;17:13–27. - PMC - PubMed
    1. Papaemmanuil E, Dohner H, Campbell PJ. Genomic classification in acute myeloid leukemia. N Engl J Med 2016;375:900–901. - PubMed
    1. Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004;32:e38. - PMC - PubMed

MeSH terms