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Comment
. 2017 Dec 5;26(6):803-804.
doi: 10.1016/j.cmet.2017.11.005.

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Inmaculada Martínez-Reyes  1 , Navdeep S Chandel  2
Affiliations
Free article
Comment

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Inmaculada Martínez-Reyes et al. Cell Metab. .
Free article

Abstract

Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

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Comment on

  • Lactate Metabolism in Human Lung Tumors.
    Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ. Faubert B, et al. Cell. 2017 Oct 5;171(2):358-371.e9. doi: 10.1016/j.cell.2017.09.019. Cell. 2017. PMID: 28985563 Free PMC article.
  • Glucose feeds the TCA cycle via circulating lactate.
    Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD. Hui S, et al. Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. Epub 2017 Oct 18. Nature. 2017. PMID: 29045397 Free PMC article.

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