RevAMPing Mitochondrial Shape to Live Longer
- PMID: 29211978
- DOI: 10.1016/j.cmet.2017.11.010
RevAMPing Mitochondrial Shape to Live Longer
Abstract
Whether and how mitochondria connect reduced energy intake to healthy aging are unclear. In this issue of Cell Metabolism, Weir et al. (2017) find that constitutive AMPK activation and dietary restriction promote longevity in C. elegans via remodeling of the mitochondrial network and fatty acid oxidation in peripheral tissues.
Copyright © 2017. Published by Elsevier Inc.
Comment on
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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.Cell Metab. 2017 Dec 5;26(6):884-896.e5. doi: 10.1016/j.cmet.2017.09.024. Epub 2017 Oct 26. Cell Metab. 2017. PMID: 29107506 Free PMC article.
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