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. 2017 Dec 5;26(6):811-813.
doi: 10.1016/j.cmet.2017.11.008.

When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

Mengrou Shan  1 , Costas A Lyssiotis  2
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When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

Mengrou Shan et al. Cell Metab. .
Free article

Abstract

In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.

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