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Editorial
. 2017 Sep 28;8(55):93297-93298.
doi: 10.18632/oncotarget.21377. eCollection 2017 Nov 7.

Cytomegalovirus pulls strings behind NK cells

Norimitsu Kadowaki  1 , Kenichi Ishiyama  1 , Toshio Kitawaki  1
Affiliations
Editorial

Cytomegalovirus pulls strings behind NK cells

Norimitsu Kadowaki et al. Oncotarget. .
No abstract available

Keywords: NK cells; Ph+ leukemia; cytomegalovirus; dasatinib; principal component analysis.

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Figures

Figure 1
Figure 1. Mechanisms of NK cell expansion in CMV-seropositive patients treated with dasatinib
In CMV-seronegative patients, CMV-associated NK cells are not observed during the whole course of CML onset and dasatinib treatment, and virtually all the NK cells are NKG2A+NKG2C-NKp30highNKp46high. In contrast, in CMV-seropositive patients, a small number of CMV-associated NKG2C+CD57+ NK cells have been generated. The CML onset appears to trigger subclinical CMV reactivation and consequent activation of the CMV-associated NK cells. Dasatinib treatment further reactivates CMV, leading to further activation and proliferation of the NK cells, which are recognized as LGLs.
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