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Editorial
. 2017 Oct 25;8(55):93315-93316.
doi: 10.18632/oncotarget.22074. eCollection 2017 Nov 7.

Combining enzalutamide with PARP inhibitors: Pharmaceutically induced BRCAness

Timothy C Thompson  1 , Likun Li  1 , Bradley M Broom  1
Affiliations
Editorial

Combining enzalutamide with PARP inhibitors: Pharmaceutically induced BRCAness

Timothy C Thompson et al. Oncotarget. .
No abstract available

Keywords: PARP inhibitors; castration-resistant prostate cancer; combination therapy; enzalutamide.

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Figures

Figure 1
Figure 1. Interactions between DDR signaling and apoptosis-related pathways underlie therapy responses to DDR-targeting therapy
Recent studies have shown that enzalutamide-induced BRCAness and PARP inhibition are synthetically lethal in experimental CRPC models [7]. These studies provide a template for future research that aims to identify optimized pharmacological parameters (e.g., dose and schedule) and to establish interactions between DDR signaling and apoptosis-related pathways using transcriptomics analysis of cancer cell and tissue samples following combination treatments with DDR-targeting agents. Bcl2L13, B-cell lymphoma 2-like 13; GADD45G, growth arrest and DNA damage inducible gamma; SGK1, serum/glucocorticoid-regulated kinase 1; TNFAIP8, tumor necrosis factor-alpha—induced protein 8.
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