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. 1989 Jan;42(1):63-72.
doi: 10.7164/antibiotics.42.63.

Synthesis and antibacterial evaluation of N-alkyl vancomycins

R Nagarajan  1 , A A Schabel, J L Occolowitz, F T Counter, J L Ott, A M Felty-Duckworth
Affiliations
Free article

Synthesis and antibacterial evaluation of N-alkyl vancomycins

R Nagarajan et al. J Antibiot (Tokyo). 1989 Jan.
Free article

Abstract

Over eighty N-alkyl vancomycins were synthesized by reductive alkylation of vancomycin with the appropriate aldehydes. The N-alkyl vancomycins exhibit greater antibacterial activity than the corresponding N-acyl vancomycins and the parent antibiotic. Some of these semisynthetic vancomycins are five times more active than vancomycin. The N-alkyl vancomycins also show longer elimination half-lives in rats than vancomycin.

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