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. 2016 Oct-Dec;10(4):296-302.
doi: 10.1590/s1980-5764-2016dn1004007.

Neuropsychological profile of Parkinson's disease patients selected for deep brain stimulation surgery

Flavia Amaral Machado  1 , Carlos Roberto Rieder  1 , Arlete Hilbig  1 , Caroline Tozzi Reppold  1
Affiliations

Neuropsychological profile of Parkinson's disease patients selected for deep brain stimulation surgery

Flavia Amaral Machado et al. Dement Neuropsychol. 2016 Oct-Dec.

Abstract
in English, Portuguese

Background: Parkinson's disease (PD) shows symptoms involving motor and non-motor complications, including cognitive and behavioral changes, such changes might to contraindicate deep brain stimulation surgery (DBS).

Objective: The aim of study was to investigate the neuropsychological profile of patients with PD in a waiting list for DBS.

Methods: The neuropsychological evaluation was held in 30 patients of the ISCMPA Movement Disorders Clinic, with surgical indication based on the criteria of the responsible neurologists, in the period of 12 months. Instruments used: MMSE, FAB, MoCA, BDI, Semantic Verbal Fluency, PDQ-39, PDSS; and the UPDRS and Hoehn-Yahr scale.

Results: The patients were mostly male (66.7%) with a mean age of 59.37 (SD 10.60) and disease duration 9.33 (SD 4.08). There was cognitive impairment in 56.7% of patients by FAB and 76.7% by MoCA.

Conclusion: Even in the earliest stages of the disease, there is the incidence of non-motor symptoms, especially in those subjects who had an early onset of the disease.

Embasamento: A doença de Parkinson (DP) apresenta sintomas que envolvem complicações motoras e não-motoras, entre elas alterações cognitivas e comportamentais, tais alterações podem contraindicar a cirurgia de estimulação cerebral profunda (DBS).

Objetivo: O objetivo de estudo foi verificar o perfil neuropsicológico dos pacientes com DP candidatos à DBS.

Métodos: Realizou-se avaliação neuropsicológica em 30 pacientes do ambulatório de Distúrbios do Movimento da ISCMPA, com indicação cirúrgica segundo critério dos neurologistas responsáveis, no período de 12 meses. Os instrumentos utilizados: MEEM, FAB, MoCA, BDI, FV Semântica, PDQ-39, PDSS; e as escalas UPDRS e Hoehn-Yahr.

Resultados: Os pacientes foram, em sua maioria, homens (66,7%), com média de idade de 59,37 (DP 10,6) e tempo de doença 9,33 (DP 4,0). Apresentaram comprometimento cognitivo em 56,7% dos pacientes segundo os escores do FAB e 76,7% segundo o MoCA.

Conclusão: Mesmo em fases mais iniciais da doença, percebe-se a incidência de sintomas não motores, principalmente naqueles sujeitos que tiveram um início de doença precoce da doença.

Keywords: Parkinson's disease; deep brain stimulation; neuropsychology; neurosurgery.

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Correlation between total score on the Montreal Cognitive Assessment (MoCa) and age at disease onset (years).
Figure 2
Figure 2
Correlation between total score on the Frontal Assessment Battery (FAB) and age at disease onset (years).
See this image and copyright information in PMC

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