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Review
. 2017:2017:2605628.
doi: 10.1155/2017/2605628. Epub 2017 Oct 29.

Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

Gaia Peluso  1 , Paola Incollingo  1 , Armando Calogero  1 , Vincenzo Tammaro  1 , Niccolò Rupealta  1 , Gaetano Chiacchio  1 , Maria Laura Sandoval Sotelo  1 , Gianluca Minieri  1 , Antonio Pisani  2 , Eleonora Riccio  2 , Massimo Sabbatini  2 , Umberto Marcello Bracale  2 , Concetta Anna Dodaro  1 , Nicola Carlomagno  1
Affiliations
Review

Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

Gaia Peluso et al. Biomed Res Int. 2017.

Abstract

Background: Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic.

Aim of the review: Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC.

Conclusion: Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice.

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