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. 2018 Mar;38(2):102-109.
doi: 10.3343/alm.2018.38.2.102.

Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes

Min Hyuk Choi  1   2 , Yu Jin Park  1 , Myungsook Kim  1 , Young Hee Seo  1 , Young Ah Kim  2 , Jun Yong Choi  3 , Dongeun Yong  1 , Seok Hoon Jeong  1 , Kyungwon Lee  4
Affiliations

Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes

Min Hyuk Choi et al. Ann Lab Med. 2018 Mar.

Erratum in

Abstract

Background: Listeriosis caused by Listeria monocytogenes has a high case-fatality rate (CFR) of approximately 20% to 30%. An increasing incidence of listeriosis has been reported in many countries recently. We investigated the annual incidence, clinical characteristics, and outcomes of listeriosis at three different hospitals in Korea and evaluated the effects of appropriate empiric antimicrobial treatments on patient outcomes.

Methods: We retrospectively collected the data of all culture-positive cases of human listeriosis from three hospitals of different sizes in Korea during 2006-2016 and calculated the annual number of cases and incidence per 100,000 admissions.

Results: A total of 58 patients with L. monocytogenes were included in this study. The incidence of listeriosis was significantly higher in 2013-2016 than in 2006-2012 (RR 3.1; 95% CI 1.79-5.36; P<0.001), mainly because of an increase in patients over 60 years of age (RR 3.69; 95% CI 1.70-8.02; P<0.001). Multivariate analysis showed that healthcare-associated infection (adjusted OR, 12.15; 95% CI, 2.56-86.01; P=0.004) and empirical treatment with first-line antimicrobial agents (adjusted OR, 0.08; 95% CI, 0.00-0.63; P=0.044) were associated with CFR.

Conclusions: Healthcare-associated infections caused by L. monocytogenes are associated with high CFR. Adequate initial empirical treatments could reduce CFR, suggesting that careful consideration of an empirical antimicrobial regimen is warranted for elderly or immunocompromised patients admitted to the hospital.

Keywords: Empirical treatment; Incidence; Listeria monocytogenes; Listeriosis; Outcome.

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Conflict of interest statement

We declare that we have no conflicts of interest.

Figures

Fig. 1
Fig. 1. Increase in the number of Listeria monocytogenes isolates according to age distribution, 2006–2016.
Fig. 2
Fig. 2. Trends in non-pregnancy-associated listeriosis categorized by (A) age distribution and (B) underlying disease, 2006–2012 vs 2013–2016.
Abbreviations: Postop, postoperative states; HM, hematologic malignancies; DM, diabetes mellitus; CRD, chronic respiratory diseases; CLD, chronic liver diseases; CKD, chronic kidney diseases.
See this image and copyright information in PMC

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