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. 2018 Jan;592(1):60-70.
doi: 10.1002/1873-3468.12932. Epub 2017 Dec 19.

ARA1 regulates not only l-arabinose but also d-galactose catabolism in Trichoderma reesei

Tiziano Benocci  1 , Maria Victoria Aguilar-Pontes  1 , Roland Sándor Kun  1 , Bernhard Seiboth  2 , Ronald P de Vries  1 , Paul Daly  1
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Free article

ARA1 regulates not only l-arabinose but also d-galactose catabolism in Trichoderma reesei

Tiziano Benocci et al. FEBS Lett. 2018 Jan.
Free article

Abstract

Trichoderma reesei is used to produce saccharifying enzyme cocktails for biofuels. There is limited understanding of the transcription factors (TFs) that regulate genes involved in release and catabolism of l-arabinose and d-galactose, as the main TF XYR1 is only partially involved. Here, the T. reesei ortholog of ARA1 from Pyricularia oryzae that regulates l-arabinose releasing and catabolic genes was deleted and characterized by growth profiling and transcriptomics along with a xyr1 mutant and xyr1/ara1 double mutant. Our results show that in addition to the l-arabinose-related role, T. reesei ARA1 is essential for expression of d-galactose releasing and catabolic genes, while XYR1 is not involved in this process.

Keywords: Trichoderma reesei; d-galactose; l-arabinose; lignocellulose degradation; metabolism; regulation.

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