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Comment
. 2017 Dec 7;23(12):1399-1400.
doi: 10.1038/nm.4454.

Organoids lead the cancer attack

Amber R Smith  1 , Calvin J Kuo  1
Affiliations
Comment

Organoids lead the cancer attack

Amber R Smith et al. Nat Med. .

Abstract

In an article published recently in Nature Medicine, the authors generate organoid models of liver neoplasia. In doing so, they highlight both the diversity of current organoid methodologies and their application to cancer modeling and therapeutics discovery.

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Figures

Figure 1
Figure 1
Organoid models of liver cancer. Broutier et al. generated tumor organoids, termed tumoroids, from liver cancer tumor biopsies spanning a range of histological types. Screening of these organoids identified a small-molecule ERK1/2 inhibitor as a potential liver cancer therapeutic and also identified potential prognostic biomarkers.
See this image and copyright information in PMC

Comment on

  • The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy.
    Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, Terakura S, Wada N, Morii E, Nishimura J, Takeda K, Oji Y, Sugiyama H, Takagi J, Kumanogoh A. Hosen N, et al. Nat Med. 2017 Dec;23(12):1436-1443. doi: 10.1038/nm.4431. Epub 2017 Nov 6. Nat Med. 2017. PMID: 29106400

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