Tradition and innovation in development of a Zika vaccine

doi:10.1016/S0140-6736(17)33107-0

Comment

. 2018 Feb 10;391(10120):516-517.

doi: 10.1016/S0140-6736(17)33107-0. Epub 2017 Dec 5.

Tradition and innovation in development of a Zika vaccine

Ernesto T A Marques¹, Donald S Burke²

Affiliations

¹ Graduate School of Public Health, and the Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; Instituto Aggeu Magalhães, Department of Virology and Experimental Therapeutics, FIOCRUZ-Pernambuco, Brazil. Electronic address: marques@pitt.edu.
² Graduate School of Public Health, and the Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

PMID: 29217377
DOI: 10.1016/S0140-6736(17)33107-0

Comment

Tradition and innovation in development of a Zika vaccine

Ernesto T A Marques et al. Lancet. 2018.

. 2018 Feb 10;391(10120):516-517.

doi: 10.1016/S0140-6736(17)33107-0. Epub 2017 Dec 5.

Authors

Ernesto T A Marques¹, Donald S Burke²

Affiliations

¹ Graduate School of Public Health, and the Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; Instituto Aggeu Magalhães, Department of Virology and Experimental Therapeutics, FIOCRUZ-Pernambuco, Brazil. Electronic address: marques@pitt.edu.
² Graduate School of Public Health, and the Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

PMID: 29217377
DOI: 10.1016/S0140-6736(17)33107-0

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Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials.
Modjarrad K, Lin L, George SL, Stephenson KE, Eckels KH, De La Barrera RA, Jarman RG, Sondergaard E, Tennant J, Ansel JL, Mills K, Koren M, Robb ML, Barrett J, Thompson J, Kosel AE, Dawson P, Hale A, Tan CS, Walsh SR, Meyer KE, Brien J, Crowell TA, Blazevic A, Mosby K, Larocca RA, Abbink P, Boyd M, Bricault CA, Seaman MS, Basil A, Walsh M, Tonwe V, Hoft DF, Thomas SJ, Barouch DH, Michael NL. Modjarrad K, et al. Lancet. 2018 Feb 10;391(10120):563-571. doi: 10.1016/S0140-6736(17)33106-9. Epub 2017 Dec 5. Lancet. 2018. PMID: 29217375 Free PMC article. Clinical Trial.
Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials.
Gaudinski MR, Houser KV, Morabito KM, Hu Z, Yamshchikov G, Rothwell RS, Berkowitz N, Mendoza F, Saunders JG, Novik L, Hendel CS, Holman LA, Gordon IJ, Cox JH, Edupuganti S, McArthur MA, Rouphael NG, Lyke KE, Cummings GE, Sitar S, Bailer RT, Foreman BM, Burgomaster K, Pelc RS, Gordon DN, DeMaso CR, Dowd KA, Laurencot C, Schwartz RM, Mascola JR, Graham BS, Pierson TC, Ledgerwood JE, Chen GL; VRC 319; VRC 320 study teams. Gaudinski MR, et al. Lancet. 2018 Feb 10;391(10120):552-562. doi: 10.1016/S0140-6736(17)33105-7. Epub 2017 Dec 5. Lancet. 2018. PMID: 29217376 Free PMC article. Clinical Trial.

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Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice.
Zhang Y, Zhang H, Ma W, Liu K, Zhao M, Zhao Y, Lu X, Zhang F, Li X, Gao GF, Liu WJ. Zhang Y, et al. J Vis Exp. 2018 Oct 17;(140):58110. doi: 10.3791/58110. J Vis Exp. 2018. PMID: 30394402 Free PMC article.

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Tradition and innovation in development of a Zika vaccine

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Tradition and innovation in development of a Zika vaccine

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