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. 2017 Sep 28;8(56):95791-95798.
doi: 10.18632/oncotarget.21327. eCollection 2017 Nov 10.

Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx

Filippo Ricciardiello  1 , Michele Caraglia  2 , Brigida Iorio  3 , Teresa Abate  1 , Mariarosaria Boccellino  2 , Giuseppe Colella  4 , Flavia Oliva  1 , Pierpaolo Ferrise  1 , Silvia Zappavigna  2 , Mario Faenza  4 , Giuseppe A Ferraro  4 , Giulio Sequino  1 , Giovanni Francesco Nicoletti  4 , Massimo Mesolella  3
Affiliations

Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx

Filippo Ricciardiello et al. Oncotarget. .

Abstract

Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract. We have evaluated disease specific survival (DSS) and overall survival (OS) through Kaplan-Meier method and mortality risk through univariate statistical analysis of Cox in 42 cases of BSCC and other 42 of laryngeal SCC (LSCC) matched for both age and sex. We demonstrated that laryngeal BSCC is a more aggressive tumor than LSCC as is associated to higher nodal recurrence of pathology (5 vs 2 patients, overall risk, OR 2.7), a reduced survival (median survival 34 vs 40 months, OR 3.2 for mortality); in addition, basaloid patients have a higher risk to be affected by second primary tumors (13 vs 3 patients, OR 5.8) and a higher probability to die for this second tumor (Hazard Risk, HR 4.4). The analysis of survival shows an increased mortality risk concurrent with the parameters assessed by univariate analyses that assume a predictive and statistical significance in second tumor and grading in basaloid LSSC.

Keywords: laryngea lbasaloid squamocellular carcinoma (BSCC); loco-regional recurrence in laryngeal BSCC; mortality of laryngeal BSCC; prognosis of laryngeal basaloid squamous cell carcinoma.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare they have no known conflicts of interest in this work.

Figures

Figure 1
Figure 1
Survival rate analysis in basaloid subgroup A (A); in non-basaloid subgroup B (B); disease specific survival comparison between two subgroups (C).
Figure 2
Figure 2
OS in basaloid A and non-basaloid B subgroups (A); survival probability in relation to follow-up period in months in basaloid subgroup B (B).
See this image and copyright information in PMC

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