Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 8;10(1):719.
doi: 10.1186/s13104-017-3015-9.

Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria

Lawrence Ehis Okoror  1 , Ayodele Oluwaseun Ajayi  2 , Oluwaseun Benjamin Ijalana  3
Affiliations

Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria

Lawrence Ehis Okoror et al. BMC Res Notes. .

Abstract

Objective: Coinfection of hepatitis B virus (HBV) with hepatitis D virus (HDV) has being reported to increase severity of progression to hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Beta microglobulin (2βM) which is present on the surfaces of blood cells in acceptable levels is a tumor marker which may become elevated in disease conditions. This study hence observed the prevalence of HBV and HDV coinfection in a rural population and their 2βM concentration.

Results: Of the 368 samples, 66 (17.9%) were positive to hepatitis B surface antigen (HBsAg) and 33 (50%) were coinfected with HDV, 8 (2.1%) were monoinfected with HDV. 2βM concentration increased beyond the normal level in individuals coinfected with HBV and HDV as compared with the monoinfected individuals. Coinfection resulted in the increased concentration of 2βM in HBV and HDV coinfection and the likelihood of progression to HCC and LC may not be ruled out. Monoinfection with HDV also had high 2βM concentration but this is due to having being infected with a non-detected HBV or chronic infection in which HBV is clearing.

Keywords: 2βmicroglobulin; Coinfection; ELISA; Hepatitis B; Hepatitis D; Monoinfection.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Average concentration of 2βM along the age groups of patients positive to HBsAg and HDV coinfection and HBsAg and HDV monoinfection
Fig. 2
Fig. 2
Concentration of 2βM in individuals positive to HBV, HDV and HBV/HDV coinfection and as related to their individual ages
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology. 2007;45(2):507–509. doi: 10.1002/hep.21513. - DOI - PubMed
    1. European Association for the Study of the Liver EASL clinical practice guidelines: management of chronic hepatitis B. J Hepatol. 2009;50(2):227–242. doi: 10.1016/j.jhep.2008.10.001. - DOI - PubMed
    1. Jawetz M. Adelbergs. Hepatitis viruses. In: Brooks GF, Butel JS, Morse SA, editors. Medical microbiology. 24 ed. Appleton and Lange; 2007.
    1. Hyams KC. Risks of chronicity following acute hepatitis B virus infection: a review. Clin Infect Dis. 1995;20:992–1000. doi: 10.1093/clinids/20.4.992. - DOI - PubMed
    1. Wang Y, Wei L, Jiang D, Cong X, Fei R, Xiao J, Wang Y. In vitro resistance to interferon of hepatitis B virus with precore mutation. World J Gastroenterol. 2005;11(5):649–655. doi: 10.3748/wjg.v11.i5.649. - DOI - PMC - PubMed

Substances