Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Feb:65:39-45.
doi: 10.1016/j.cct.2017.11.015. Epub 2017 Dec 6.

The relationship of Physical performance and Osteoporosis prevention with vitamin D in older African Americans (PODA)

Ruban Dhaliwal  1 , Mageda Mikhail  2 , Gianina Usera  2 , Alexandra Stolberg  2 , Shahidul Islam  2 , Louis Ragolia  2 , John F Aloia  2
Affiliations
Randomized Controlled Trial

The relationship of Physical performance and Osteoporosis prevention with vitamin D in older African Americans (PODA)

Ruban Dhaliwal et al. Contemp Clin Trials. 2018 Feb.

Abstract

Rationale: Vitamin D deficiency is associated with bone loss, poor muscle strength, falls and fracture. This information in older African Americans (AAs) is sparse.

Objective: The study of the relationship of Physical performance, Osteoporosis prevention with vitamin D in older African Americans (PODA) is a randomized, double-blind, placebo-controlled 3-year trial examining the effect of vitamin D on bone loss and physical performance in older AA women.

Methods: 260 healthy AA women aged >60years were assigned to receive placebo or vitamin D3. Initial vitamin D3 dose was determined by the baseline serum 25OHD level, and adjusted further to maintain serum 25OHD between 30 and 69ng/ml. Subjects with baseline 25OHD levels ≤8ng/ml or ≥26ng/ml were excluded. Objective measures of neuromuscular strength [Short Physical Performance Battery (SPPB), grip strength and 6-minute walking distance (6MWD)] and bone mineral density (BMD) were obtained.

Results: SPPB gait speed, grip strength and 6MWD showed a significant positive correlation with free 25OHD. 1pg/ml increase in free 25OHD predicted a 32% increase in the odds of having higher gait speed and a 1.42lb. increase in grip strength. No significant differences in BMI, BMD, muscle mass, grip strength, serum total 25OHD and free 25OHD were observed between groups. None of the measures of physical performance showed an association with baseline serum 25OHD.

Conclusions: This is the first study to show an association between free 25OHD and physical performance. These findings indicate a positive relationship of free 25OHD with gait speed and grip strength in older AA women. Further studies are needed to understand the role of free 25OHD.

Keywords: African American; Free vitamin D; Muscle strength; Physical performance; Vitamin D.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Each author certifies that he/she has no commercial associations.

Figures

Figure 1
Figure 1
Relationship between Free 25OHD and Grip Strength
See this image and copyright information in PMC

References

    1. Looker AC, Pfeiffer CM, Lacher DA, et al. Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004. Am J Clin Nutr. 2008;88(6):1519–27. - PMC - PubMed
    1. Ross AC, Taylor CL, Yaktine AL, et al. Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium . Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press; 2011. - PubMed
    1. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. - PubMed
    1. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7(5):439–43. - PubMed
    1. Guillemant J, Le HT, Maria A, et al. Wintertime vitamin D deficiency in male adolescents: effect on parathyroid function and response to vitamin D3 supplements. Osteoporos Int. 2001;12(10):875–9. - PubMed

Publication types