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Comment
. 2018 Jan 15;83(2):e27-e29.
doi: 10.1016/j.biopsych.2017.11.017.

From "Azalla" to Anandamide: Distilling the Therapeutic Potential of Cannabinoids

Rajiv Radhakrishnan  1 , David A Ross  2
Affiliations
Comment

From "Azalla" to Anandamide: Distilling the Therapeutic Potential of Cannabinoids

Rajiv Radhakrishnan et al. Biol Psychiatry. .
No abstract available

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Conflict of interest statement

Disclosures

The authors report no biomedical financial interests or potential conflicts of interest.

Figures

Figure 1
Figure 1
Endocannabinoid synthesis and signaling. (1) Endocannabinoids (anandamide and 2-arachidonyl glycerol [2-AG]) are synthesized in the postsynaptic terminal in response to the activation of metabotropic glutamate receptor 1 and 5 (mGluR1/5) receptors. (2) Anandamide and 2-AG diffuse out of the postsynaptic terminal back into the synaptic cleft. (3) Anandamide and 2-AG bind to cannabinoid receptor 1 (CB1R) on the presynaptic terminal (“retrograde signaling”). (4) The activation of CB1R suppresses further release of the neurotransmitter. AMPAR, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; Na, sodium.
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