Autophagy Inhibition in Pancreatic Adenocarcinoma

Abstract

Although some progress has been made in recent years with the development of more effective chemotherapy regimens, new treatment approaches are needed to improve outcomes for patients with pancreatic adenocarcinoma. The cellular process of autophagy, a cell survival mechanism that allows cancer cells to survive the hazardous conditions of the tumor microenvironment and treatment, has emerged as a viable target in pancreatic cancer. We review the mechanism of autophagy, its role in pancreatic carcinogenesis, the preclinical and clinical evidence supporting targeting autophagy in patients with pancreatic adenocarcinoma, and areas of future investigation that hold promise for improving this treatment approach.

Keywords: Apoptosis; Chloroquine; Damage-associated molecular pattern molecule (DAMP); High-mobility group box 1 (HMGB1); Hydroxychloroquine.