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. 2018 Jul-Aug:50:5-12.
doi: 10.1016/j.clinimag.2017.12.001. Epub 2017 Dec 5.

Characteristics of computed tomography perfusion parameters in non-small-cell-lung-cancer and its relationship to histology, size, stage an treatment response

Carmen Trinidad López  1 , Miguel Souto Bayarri  2 , Roque Oca Pernas  3 , Carlos Delgado Sánchez-Gracián  4 , Maria González Vázquez  5 , Antonio Vaamonde Liste  6 , Gonzalo Tardáguila De La Fuente  7 , Javier De La Fuente Aguado  8
Affiliations

Characteristics of computed tomography perfusion parameters in non-small-cell-lung-cancer and its relationship to histology, size, stage an treatment response

Carmen Trinidad López et al. Clin Imaging. 2018 Jul-Aug.

Abstract

Objectives: To analyze computed tomography perfusion (CTP) parameters in NSCLC.

Materials and methods: Prospective study, 152 patients with NSCLC. CTP parameters were correlated with histology, stage, size and response to conventional chemotherapy/radiotherapy.

Results: Neuroendocrine tumours presented higher BV (p 0.002). Negative correlation of PMB (p 0.003) and positive of MTT (p 0.046) with T stage was found. BF showed negative correlation with size. No differences were found with the RECIST levels of response to chemotherapy/radiotherapy.

Conclusions: CTP parameters were highly variable. Neuroendocrine tumours presented higher BV and PMB values. Perfusion parameters do not differ depending on the stage and do not predict response to treatment.

Keywords: Computed tomography; Imaging biomarker; Lung; Lung cancer; Perfusion imaging.

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