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. 2018 Feb;24(2):150-152.
doi: 10.1016/j.jiac.2017.09.008. Epub 2017 Dec 6.

Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak

Jae-Hoon Ko  1 , Hyeri Seok  1 , Ga Eun Park  1 , Ji Yeon Lee  1 , Ji Yong Lee  1 , Sun Young Cho  1 , Young Eun Ha  1 , Ji-Man Kang  2 , Yae-Jean Kim  2 , Cheol-In Kang  1 , Doo Ryeon Chung  1 , Jae-Hoon Song  1 , Kyong Ran Peck  3
Affiliations

Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak

Jae-Hoon Ko et al. J Infect Chemother. 2018 Feb.

Abstract

To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447-178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402-13.761; P = 0.011) were significantly associated with MERS-CoV infection.

Keywords: Middle East respiratory syndrome coronavirus; Stem cell transplantation; Susceptibility; Tachypnea.

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