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Review
. 2017 Jun;31(3):351-363.
doi: 10.1016/j.berh.2017.10.002. Epub 2017 Nov 6.

Diagnostic and prognostic tests in systemic lupus erythematosus

Natalia Vasquez-Canizares  1 , Dawn Wahezi  1 , Chaim Putterman  2
Affiliations
Review

Diagnostic and prognostic tests in systemic lupus erythematosus

Natalia Vasquez-Canizares et al. Best Pract Res Clin Rheumatol. 2017 Jun.

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the "omics" era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.

Keywords: Biomarkers; Epigenetics; Genomics; Lupus nephritis; Metabolomics; Proteomics; Systemic lupus erythematosus; Transcriptomics.

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