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Review
. 2017 Apr;31(2):218-242.
doi: 10.1016/j.berh.2017.11.007. Epub 2017 Nov 21.

Sarcopenia

Nicholas Fuggle  1 , Sarah Shaw  2 , Elaine Dennison  3 , Cyrus Cooper  4
Affiliations
Review

Sarcopenia

Nicholas Fuggle et al. Best Pract Res Clin Rheumatol. 2017 Apr.

Abstract

Sarcopenia is a condition that is characterized by loss of muscle mass, muscle strength and muscle functional impairment with ageing. The definition of sarcopenia has been through various permutations; however, an enormous recent breakthrough is the inclusion of the condition in the ICD-10 classification of diseases. This chapter covers the background issues regarding definition before describing the epidemiology of the disease according to human and environmental factors. It then provides a practical guide for the assessment of sarcopenia in a clinical setting and finishes with advice on present treatment and the exciting frontiers of future therapies.

Keywords: Ageing; Function; Muscle; Sarcopenia; Strength.

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Conflict of interest statement

Conflicts of interest

None to declare

Figures

Figure 1
Figure 1
Flow diagram depicting demonstrating the development and propagation of sarcopenia.
Figure 2
Figure 2
Used with author permission [19]. Cross-cohort centile curves for grip strength. Centiles shown 10, 25th, 50th, 75th and 90th. ADNFS Allied Dunbar National Fitness Survey, ALSPAC Avon Longitudinal Study of Parents and Children, ELSA English Longitudinal Study of Ageing, HAS Hertfordshire Ageing Study, HCS Hertfordshire Cohort Study, LBC1921 and LBC1936 Lothian Birth Cohorts of 1921 and 1936, N85 Newcastle 85+ Study, NSHD Medical Research Council National Survey of Health and Development, SWS Southampton Women’s Survey, SWSmp mothers and their partners from the SWS, T-07 West of Scotland Twenty-07 Study, UKHLS Understanding Society: the UK Household Panel Study.
Figure 3
Figure 3
Used with author permission [29]. Grip strength mean values from included samples, by UN region. Each point represents the mean value of grip strength for each item of normative data, plotted against the mid-point of the age range it relates to. Values from the same sample are connected. Data from developing and developed regions are shown with triangles and circles, respectively. For comparison, the grey curve shows the mean values from our normative data for 12 British studies.
Figure 4
Figure 4
A schema depicting the anabolic and catabolic factors influencing the development of sarcopenia and the interventions which could influence each factor
See this image and copyright information in PMC

References

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