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. 2017 Dec 25;82(1):10-16.
doi: 10.1253/circj.CJ-17-1184. Epub 2017 Dec 8.

Metabolomic Analysis in Heart Failure

Ryutaro Ikegami  1 , Ippei Shimizu  1   2 , Yohko Yoshida  1   2 , Tohru Minamino  1
Affiliations
Free article

Metabolomic Analysis in Heart Failure

Ryutaro Ikegami et al. Circ J. .
Free article

Abstract

It is thought that at least 6,500 low-molecular-weight metabolites exist in humans, and these metabolites have various important roles in biological systems in addition to proteins and genes. Comprehensive assessment of endogenous metabolites is called metabolomics, and recent advances in this field have enabled us to understand the critical role of previously unknown metabolites or metabolic pathways in the cardiovascular system. In this review, we will focus on heart failure and how metabolomic analysis has contributed to improving our understanding of the pathogenesis of this critical condition.

Keywords: Amino acids; Fatty acids; Glucose; Ketones; Metabolome.

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