Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017;5(32):6523-6535.
doi: 10.1039/C7TB00855D. Epub 2017 Jul 8.

Fullerenes in Biology and Medicine

Edison Castro  1 , Andrea Hernandez Garcia  1 , Gerardo Zavala  1 , Luis Echegoyen  1
Affiliations

Fullerenes in Biology and Medicine

Edison Castro et al. J Mater Chem B. 2017.

Abstract

Fullerenes and related carbon based derivatives have shown a growing relevance in biology and medicine, mainly due to the unique electronic and structural properties that make them excellent candidates for multiple functionalization. This review focuses on the most recent developments of fullerene derivatives for different biological applications.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
First water-soluble and biologically active fullerene derivative reported.
Fig. 2
Fig. 2. Maturation inhibitor fullerene derivatives
Fig. 3
Fig. 3
Structure of the anti HIV-1 [60]fullerene derivatives 7-24.
Fig. 4
Fig. 4
Fucofullerenes and their corresponding monomeric controls. Reproduced from Ref. with permission from The Royal Society of Chemistry.
Fig. 5
Fig. 5
Giant globular multivalent glycofullerenes. Reprinted by permission from Macmillan Publishers Ltd: Nature Chemistry, Muñoz et al. copyright (2016).
Fig. 6
Fig. 6
Fullerene derivatives for PDT applications.
Fig. 7
Fig. 7
Fullerene derivatives for photodynamic therapy.
Fig. 8
Fig. 8
Exchange method used for the preparation of the LMIC60 derivatives. a) Rapid mixing of two solutions and b) Injection. Reproduced from Ikeda et al. with permission from The Royal Society of Chemistry.
Fig. 9
Fig. 9
Possible mechanisms for lipid peroxyl radical (LOO●) scavenging by fullerenols C60(OH)n: a) addition to C=C bonds and b) H-abstraction from -OH groups. Adapted from Ueno et al. (2014).
Fig. 10
Fig. 10
Schematic illustrating the conjugation of fullerenols on CNC. Reprinted from Awan et al. (2016), with permission of Springer.
Fig. 11
Fig. 11
Fullerene derivatives with anticancer properties.
Fig. 12
Fig. 12
Fullerene derivatives with immunological properties.
Fig. 13
Fig. 13
Functionalization of Gd-EMFs. Reprinted with permission from Li et al. Copyright (2016) Wiley-VCH and Sons.
Fig. 14
Fig. 14
IL-13-Gd3N@C80(OH)x(NH2)y nanoparticles with positive charges illustrating facile binding to a negatively charged phospholipid bilayer cellular surfaces. Reprinted with permission from Li et al. Copyright (2015) American Chemical Society.
Fig. 15
Fig. 15
The possible mechanism by which back transfusion of macrophages activated by Gd@C82(OH)22 nanoparticles inhibit tumor metastasis. Reprinted from Tang et al. Copyright (2016), with permission from Elsevier.
See this image and copyright information in PMC

References

    1. Kroto HW, Heath JR, O'Brien SC, Curl RF, Smalley RE. Nature. 1985;318:162–163.
    1. Hawkins JM, Lewis TA, Loren SD, Meyer A, Heath JR, Shibato Y, Saykally RJ. J Org Chem. 1990;55:6250–6252. - PubMed
    1. Kratschmer W, Lamb LD, Fostiropoulos K, Huffman DR. Nature. 1990;347:354–358.
    1. Wudl F. Acc Chem Res. 1992;25:157–161.
    1. Sijbesma R, Srdanov G, Wudl F, Castoro JA, Wilkins C, Friedman SH, DeCamp DL, Kenyon GL. J Am Chem Soc. 1993;115:6510–6512.

LinkOut - more resources