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. 1989 Feb 24;243(4894 Pt 1):1056-9.
doi: 10.1126/science.2922595.

Specific recognition of cruciform DNA by nuclear protein HMG1

M E Bianchi  1 , M Beltrame, G Paonessa
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Specific recognition of cruciform DNA by nuclear protein HMG1

M E Bianchi et al. Science. .

Abstract

Cruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in genetic recombination as well as from palindromic sequences under the effect of supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively recognizes cruciform DNA. Biochemical and immunological data showed that this protein is HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus. The interaction with a ubiquitous protein points to a critical role for cruciform DNA conformations.

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