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. 2018 Feb;18(2):81-82.
doi: 10.1038/nri.2017.139. Epub 2017 Dec 11.

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism

Edward J Pearce  1 , Erika L Pearce  2
Affiliations

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism

Edward J Pearce et al. Nat Rev Immunol. 2018 Feb.

Abstract

In 2017, studies of cellular metabolism broadly permeated immunological research. Accumulating data support the view that understanding how metabolism regulates immune cell function could provide new therapeutic opportunities for the many diseases associated with immune system dysregulation.

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Conflict of interest statement

Competing interests statement

The authors declare competing interests. See online for details.

Figures

Figure 1 |
Figure 1 |. Metabolic programmes regulate immune cell function.
a | In microglia, signalling through triggering receptor expressed on myeloid cells 2 (TREM2) promotes activation of mechanistic target of rapamycin (mTOR), which balances anabolic metabolism and ATP production. b | Positive effects of the microbiota on influenza virus infection are mediated by the microbial metabolite desaminotyrosine (DAT), which potentiates signalling downstream of the type I interferon receptor (IFNAR). c | Metabolic support for natural killer (NK) cell activation by IL-2 and IL-12 is provided by induced expression of sterol regulatory element binding protein 1 (SREBP1), which upregulates expression of SLC25A1. This citrate–malate shuttle enables NADH to be moved into mitochondria, where it fuels ATP production. d | (Amino-oxy)acetic acid (AOA) limits T helper 17 (TH17) cell development by inhibiting the activity of aspartate aminotransferase, cytoplasmic (AATC), which catalyses the conversion of glutamate into α-ketoglutarate (α-KG; the precursor of 2-hydroxyglutarate (2-HG)). 2-HG promotes the methylation and transcriptional inactivation of Foxp3. OAA, oxaloacetic acid.
See this image and copyright information in PMC

References

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