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Review
. 2018 Apr;46(4):625-634.
doi: 10.1097/CCM.0000000000002851.

Septic Cardiomyopathy

Sarah J Beesley  1   2 , Gerhard Weber  3 , Todd Sarge  4 , Sara Nikravan  5 , Colin K Grissom  1   2 , Michael J Lanspa  1 , Sajid Shahul  6 , Samuel M Brown  1   2
Affiliations
Review

Septic Cardiomyopathy

Sarah J Beesley et al. Crit Care Med. 2018 Apr.

Abstract

Objectives: To describe, with an emphasis on clinical applications, what is known about the pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU.

Data sources and study selection: A PubMed literature review was performed for relevant articles. Only articles in English that studied human adults with sepsis were included.

Data extraction and data synthesis: Multiple competing definitions for septic cardiomyopathy hinder understanding of this entity. Although many patients with sepsis develop cardiac dysfunction, the impact of septic cardiomyopathy on prognosis and therapy remains to be demonstrated. Treatment of septic cardiomyopathy is aimed at treating the underlying sepsis and providing specific supportive care for cardiogenic shock when present.

Conclusions: Septic cardiomyopathy is an important contributor to organ dysfunction in sepsis. Guided treatment of septic cardiomyopathy may affect patients' prognosis, especially when their cardiac index is substantially decreased. The implication of septic cardiomyopathy for both short- and long-term outcomes is an important area for future investigation.

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Comment in

  • Septic Cardiomyopathy and Bacterial Exotoxins.
    Monticelli J, Di Bella S, Di Masi A, Zennaro C, Tonon F, Luzzati R. Monticelli J, et al. Crit Care Med. 2018 Sep;46(9):e965-e966. doi: 10.1097/CCM.0000000000003217. Crit Care Med. 2018. PMID: 30113388 No abstract available.
  • The authors reply.
    Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ, Shahul S, Brown SM. Beesley SJ, et al. Crit Care Med. 2018 Sep;46(9):e965-e966. doi: 10.1097/CCM.0000000000003280. Crit Care Med. 2018. PMID: 30113389 No abstract available.
  • Temporary Mechanical Support in Septic Cardiomyopathy.
    George P, Ludmir J, McCurdy MT. George P, et al. Crit Care Med. 2018 Oct;46(10):e1013. doi: 10.1097/CCM.0000000000003251. Crit Care Med. 2018. PMID: 30216319 No abstract available.
  • The authors reply.
    Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ, Shahul S, Brown SM. Beesley SJ, et al. Crit Care Med. 2018 Oct;46(10):e1013-e1014. doi: 10.1097/CCM.0000000000003331. Crit Care Med. 2018. PMID: 30216320 No abstract available.