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Review
. 2017 Dec 27;117(24):14015-14041.
doi: 10.1021/acs.chemrev.7b00522. Epub 2017 Dec 11.

Small Bioactive Peptides for Biomaterials Design and Therapeutics

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Review

Small Bioactive Peptides for Biomaterials Design and Therapeutics

I W Hamley. Chem Rev. .

Abstract

This review is aimed to provide a concise yet extensive survey of key short bioactive peptide sequences for a range of applications ranging from biomaterials development to peptides with therapeutic uses. The following are considered: cell adhesion motifs, structural peptides, cell-penetrating and tumor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid peptides, antioxidant peptides, peptide affinity tags, anticancer peptides, and others. This review provides a convenient resource, summarizing a broad range of important sequences with great utility as a resource concerning both small peptide drugs and also novel biofunctional peptide-based materials.

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