Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen

Wei Gao¹, Benjamin P Howden², Timothy P Stinear³

Affiliations

¹ Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia.
² Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia; Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia.
³ Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia. Electronic address: tstinear@unimelb.edu.au.

PMID: 29227922
DOI: 10.1016/j.mib.2017.11.030

Review

Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen

Wei Gao et al. Curr Opin Microbiol. 2018 Feb.

. 2018 Feb:41:76-82.

doi: 10.1016/j.mib.2017.11.030. Epub 2017 Dec 9.

Authors

Wei Gao¹, Benjamin P Howden², Timothy P Stinear³

Affiliations

¹ Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia.
² Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia; Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia.
³ Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia. Electronic address: tstinear@unimelb.edu.au.

PMID: 29227922
DOI: 10.1016/j.mib.2017.11.030

Abstract

Enterococci are long-standing members of the human microbiome and they are also widely distributed in nature. However, with the surge of antibiotic-resistance in recent decades, two enterococcal species (Enterococcus faecalis and Enterococcus faecium) have emerged to become significant nosocomial pathogens, acquiring extensive antibiotic resistance. In this review, we summarize what is known about the evolution of virulence in E. faecium, highlighting a specific clone of E. faecium called ST796 that has emerged recently and spread globally.

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Comment in

Editorial overview: Host-pathogen interactions shaped through evolutionary and regulatory processes.
Buchrieser C, Mecsas J. Buchrieser C, et al. Curr Opin Microbiol. 2018 Feb;41:v-viii. doi: 10.1016/j.mib.2018.02.001. Curr Opin Microbiol. 2018. PMID: 29559085 No abstract available.

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Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen

Affiliations

Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen

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