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. 2017 Oct 5;8(58):99057-99065.
doi: 10.18632/oncotarget.21519. eCollection 2017 Nov 17.

Comparisons of health-related quality of life among surgery and radiotherapy for localized prostate cancer: a systematic review and meta-analysis

Cheng Chen #  1 , Zhen Chen #  1 , Kun Wang  1 , Linkun Hu  2 , Renfang Xu  1 , Xiaozhou He  1
Affiliations

Comparisons of health-related quality of life among surgery and radiotherapy for localized prostate cancer: a systematic review and meta-analysis

Cheng Chen et al. Oncotarget. .

Abstract

The objective of this study is to compare health-related quality of life (QOL) outcomes between radical prostatectomy (RP) and external beam radiation therapy (EBRT) for localized prostate cancer. PubMed, EMBASE, the Cochrane Library and Web of Science (to July 2017) were searched. Pooled analysis of each domain-specific score was calculated in relevant studies, and its change with follow-up time was explored by sub-group analysis. A total of six studies containing 4423 patients were included. Men underwent RP was associated with worse urinary and sexual domain score than EBRT (standardized mean difference (SMD) = -0.59, -0.58; 95% confidence interval (CI) = -0.73 to -0.45, -0.72 to -0.44). In contrast, EBRT group had lower bowel domain score than RP group (SMD = 0.42, 95% CI = 0.33 to 0.52). The sub-group analysis revealed the most severe urinary and sexual QOL in RP as well as bowel QOL in EBRT group all happened in the first month post operation. The different performance of two treatments in three QOL domains diminished afterwards. Health-related QOL should be considered comprehensively when planning follow-up for men after RP or EBRT for localized prostate cancer.

Keywords: prostatectomy; prostatic neoplasms; quality of life; radiotherapy.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart illustrating the selection of studies for this meta-analysis
Figure 2
Figure 2. Forest plot showing urinary QOL of RP compared with EBRT
Figure 3
Figure 3. Forest plot showing sexual QOL of RP compared with EBRT
Figure 4
Figure 4. Forest plot showing bowel QOL of RP compared with EBRT
Figure 5
Figure 5
Sub-group analyses in urinary (A), sexual (B) and bowel (C) QOL stratified by follow-up time.
See this image and copyright information in PMC

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