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. 2017 May 16;8(58):99112-99124.
doi: 10.18632/oncotarget.17944. eCollection 2017 Nov 17.

Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease

Yu Sun #  1   2 , Yafei Wang #  1 , Jiaming Lu #  3 , Rengyuan Liu  4 , Christopher G Schwarz  5 , Hui Zhao  4 , Yue Zhang  1 , Lingyi Xu  1 , Bin Zhu  3 , Bing Zhang  3 , Bing Liu  6 , Suiren Wan  1 , Yun Xu  4
Affiliations

Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease

Yu Sun et al. Oncotarget. .

Abstract

Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n=33), mild cognitive impairment (MCI group, n=31) and Alzheimer's disease (AD group, n=27) was investigated in this study. The result shows significant differences of functional connectivity in 3 pairs of regions among NC group, MCI group and AD group: right perirhinal cortex with right hippocampus tail, left perirhinal cortex with right hippocampus tail, and right parahippocampal cortex with right hippocampus head. Clustering methods were used to classify NC group, MCI group and AD group (accuracy=100%) as well as different subtypes of mild cognitive impairment patients based on functional alterations. Functional connectivity disrupted between perirhinal and parahippocampal cortex with hippocampal subfields, which may provide a better understanding of the neurodegenerative progress of MCI and AD.

Keywords: AD; MCI; functional connectivity; parahippocampal cortex; perirhinal cortex.

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Conflict of interest statement

CONFLICTS OF INTEREST I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed. I would also verify on behalf of my co-authors that NO organization may stand to gain financially now or in the future by the study. NO actual or potential conflicts of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the work submitted that could inappropriately influence (bias) their work. All patients in our study provided written informed consent and the study was conducted according to the provisions of the Helsinki declaration.

Figures

Figure 1
Figure 1. Segmentation of the bilateral hippocampi, which shows the volume rendering of the parcellation results
Subfields are denoted by different colors. Head_R: right hippocampus head. Head_L: left hippocampus head. Body_R: right hippocampus body. Body_L: left hippocampus body. Tail_R: right hippocampus tail. Tail_L: left hippocampus tail.
Figure 2
Figure 2. The spherical process of the left parahippocampal cortex (PHC_L) in REST
(a) The irregular regions in red is the original PHC_L mask which is shown in sagittal, coronal and cross section. (b) The sphered regions in red is the re-designed Head_R mask shown in sagittal, coronal and cross section.
Figure 3
Figure 3. Four functional connectivity combinations
Figure (a) and (b) are the connecting between PRC ROIs with 6 hippocampal subfields. Figure (c) and (d) are connecting between PHC ROIs with 6 hippocampal subfields.
Figure 4
Figure 4. Different functional connectivity among the NC, MCI and AD groups
Figure 5
Figure 5. Hierarchical clustering chart of among AD, MCI and NC groups
Figure 6
Figure 6. Gaussian mixture method of among AD, MCI and NC groups
Figure 7
Figure 7. K-means clustering method of among AD, MCI and NC groups
Figure 8
Figure 8. The clustering chart of two groups of MCI by GMM
The red and blue groups represent each of the MCI subtypes, respectively.
See this image and copyright information in PMC

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