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. 2017 Oct;22(4):609-617.
doi: 10.1177/2156587216687696. Epub 2017 Jan 17.

The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats

Abolfazl Akbari  1 , Khadijeh Nasiri  2 , Mojtaba Heydari  3 , Seyed Hamdollah Mosavat  3 , Aida Iraji  4
Affiliations

The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats

Abolfazl Akbari et al. J Evid Based Complementary Altern Med. 2017 Oct.

Abstract

This study was conducted to evaluate the prophylactic effect of ginger extract on ethanol-induced reproductive toxicity in male rats. Twenty-eight adult male Sprague-Dawley rats were randomly divided into 4 groups and treated daily for 28 days as follows: control, control-ginger (1 g/kg of body weight [BW]/day by gavage), ethanol group (ethanol 4 g/kg of BW/day by gavage), and ginger-ethanol group. At the end of the experiment, all the rats were sacrificed and their testes were removed and used for measurement of the total homocysteine (tHcy), trace elements, antioxidant enzymes activity, and malondialdehyde (MDA). The results in the ethanol group indicate that ethanol decreased antioxidant enzymes activity and increased MDA and tHcy compared with the control groups ( P < .05). In ginger-ethanol group, ginger improved antioxidant enzymes activity and reduced tHcy and MDA compared to ethanol group ( P < .05). It can be concluded that ginger protects the ethanol-induced testicular damage and improves the hormonal levels, trace elements, antioxidant enzymes activity, and decreases tHcy and MDA.

Keywords: Zingiber officinale Roscoe; ethanol; ginger; oxidative stress; testis; traditional medicine.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison of superoxide dismutase (SOD) (A), glutathione peroxidase (GPx) (B), catalase (CAT) (C), and malondialdehyde (MDA) (D) activity and total homocysteine (tHcy) (E) among the control and treated rats (n = 6). Values represent mean ± standard error of the mean of enzyme activity (U/mg protein of testes tissue). Asterisk show significant difference with other groups (P < .05).
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