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Review
. 2017 Nov:132:170-177.
doi: 10.1016/j.rmed.2017.10.014. Epub 2017 Oct 24.

Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology

Renjithkumar Kalikkot Thekkeveedu  1 , Milenka Cuevas Guaman  2 , Binoy Shivanna  3
Affiliations
Review

Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology

Renjithkumar Kalikkot Thekkeveedu et al. Respir Med. 2017 Nov.

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of primarily premature infants that results from an imbalance between lung injury and repair in the developing lung. BPD is the most common respiratory morbidity in preterm infants, which affects nearly 10, 000 neonates each year in the United States. Over the last two decades, the incidence of BPD has largely been unchanged; however, the pathophysiology has changed with the substantial improvement in the respiratory management of extremely low birth weight (ELBW) infants. Here we have attempted to comprehensively review and summarize the current literature on the pathogenesis and pathophysiology of BPD. Our goal is to provide insight to help further progress in preventing and managing severe BPD in the ELBW infants.

Keywords: Bronchopulmonary dysplasia; Hyperoxia; Lung function; Pathogenesis; Pathophysiology; Ventilator-induced lung injury.

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Conflict of interest statement

Disclosure

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Overview of BPD pathogenesis
Figure 2
Figure 2
Gestational age (GA) and BPD incidence
Figure 3
Figure 3
Pulmonary function testing in BPD
See this image and copyright information in PMC

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