Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic

doi:10.1128/AAC.01892-17

Case Reports

. 2018 Jan 25;62(2):e01892-17.

doi: 10.1128/AAC.01892-17. Print 2018 Feb.

Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic

Denis Malvy¹, Marylin Torrentino-Madamet^{2

3

4}, Coralie L'Ollivier^{5

6}, Marie-Catherine Receveur¹, Fakhri Jeddi^{5

6}, Laurence Delhaes⁷, Renaud Piarroux^{5

6}, Pascal Millet⁷, Bruno Pradines^{8

3

4}

Affiliations

¹ Service des Maladies Infectieuses et Tropicales, Hôpital Pellegrin, Bordeaux, France.
² Unité Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
³ Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France.
⁴ Centre National de Référence du Paludisme, Marseille, France.
⁵ Laboratoire de Parasitologie, Hôpital la Timone, Marseille, France.
⁶ Aix Marseille Université, Unité Mixte de Recherche MD3, Marseille, France.
⁷ Laboratoire de Parasitologie -Mycologie, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France.
⁸ Unité Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France bruno.pradines@gmail.com.

PMID: 29229635
PMCID: PMC5786779
DOI: 10.1128/AAC.01892-17

Case Reports

Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic

Denis Malvy et al. Antimicrob Agents Chemother. 2018.

. 2018 Jan 25;62(2):e01892-17.

doi: 10.1128/AAC.01892-17. Print 2018 Feb.

Authors

Affiliations

¹ Service des Maladies Infectieuses et Tropicales, Hôpital Pellegrin, Bordeaux, France.
² Unité Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
³ Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France.
⁴ Centre National de Référence du Paludisme, Marseille, France.
⁵ Laboratoire de Parasitologie, Hôpital la Timone, Marseille, France.
⁶ Aix Marseille Université, Unité Mixte de Recherche MD3, Marseille, France.
⁷ Laboratoire de Parasitologie -Mycologie, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France.
⁸ Unité Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France bruno.pradines@gmail.com.

PMID: 29229635
PMCID: PMC5786779
DOI: 10.1128/AAC.01892-17

Abstract

We report evidence, confirmed by the lack of travel activity outside of France and genetic diversity analysis using polymorphic microsatellite markers, that Plasmodium falciparum malaria infection effectively treated with an artemisinin-based combination can remain dormant and relapse during pregnancy at least 2 years after treatment.

Keywords: Plasmodium falciparum; antimalarial drug; in vitro; in vivo; malaria; molecular marker; resistance.

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References

1. D'Ortenzio E, Godineau N, Fontanet A, Houze S, Bouchaud O, Matheron S, Le Bras J. 2008. Prolonged Plasmodium falciparum infection in immigrants, Paris. Emerg Infect Dis 14:323–326. doi:10.3201/eid1402.061475. - DOI - PMC - PubMed
1. Theunissen C, Janssens P, Demulder A, Nouboussié D, Van-Esbroeck M, Van-Gompel A, Van-Denende J. 2009. Falciparum malaria in patient 9 years after leaving malaria-endemic area. Emerg Infect Dis 15:115–116. doi:10.3201/eid1501.080909. - DOI - PMC - PubMed
1. Anderson TJC, Haubold B, Williams JT, Estrada-Franco JG, Richardson L, Mollinedo R, Bockarie M, Mokili J, Mharakurwa S, French N, Whitworth J, Velez ID, Brockman AH, Nosten F, Ferreira MU, Day KP. 2000. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol Biol Evol 17:1467–1482. doi:10.1093/oxfordjournals.molbev.a026247. - DOI - PubMed
1. Savini H, Bogreau H, Bertaux L, Bouchiba H, Kraemer P, Parzy D, Garnotel E, Rogier C, Simon F, Pradines B. 2008. First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros. Antimicrob Agents Chemother 52:2283–2284. doi:10.1128/AAC.00282-08. - DOI - PMC - PubMed
1. Javelle E, Madamet M, Gaillard T, Velut G, Surcouf C, Michel R, Garnotel E, Simon F, Pradines B. 2016. Delayed P. falciparum malaria after doxycycline prophylaxis, Central African Republic. Antimicrob Agents Chemother 60:2592–2593. doi:10.1128/AAC.01858-15. - DOI - PMC - PubMed

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[1] D'Ortenzio E, Godineau N, Fontanet A, Houze S, Bouchaud O, Matheron S, Le Bras J. 2008. Prolonged Plasmodium falciparum infection in immigrants, Paris. Emerg Infect Dis 14:323–326. doi:10.3201/eid1402.061475. - DOI - PMC - PubMed

[2] D'Ortenzio E, Godineau N, Fontanet A, Houze S, Bouchaud O, Matheron S, Le Bras J. 2008. Prolonged Plasmodium falciparum infection in immigrants, Paris. Emerg Infect Dis 14:323–326. doi:10.3201/eid1402.061475. - DOI - PMC - PubMed

[3] Theunissen C, Janssens P, Demulder A, Nouboussié D, Van-Esbroeck M, Van-Gompel A, Van-Denende J. 2009. Falciparum malaria in patient 9 years after leaving malaria-endemic area. Emerg Infect Dis 15:115–116. doi:10.3201/eid1501.080909. - DOI - PMC - PubMed

[4] Theunissen C, Janssens P, Demulder A, Nouboussié D, Van-Esbroeck M, Van-Gompel A, Van-Denende J. 2009. Falciparum malaria in patient 9 years after leaving malaria-endemic area. Emerg Infect Dis 15:115–116. doi:10.3201/eid1501.080909. - DOI - PMC - PubMed

[5] Anderson TJC, Haubold B, Williams JT, Estrada-Franco JG, Richardson L, Mollinedo R, Bockarie M, Mokili J, Mharakurwa S, French N, Whitworth J, Velez ID, Brockman AH, Nosten F, Ferreira MU, Day KP. 2000. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol Biol Evol 17:1467–1482. doi:10.1093/oxfordjournals.molbev.a026247. - DOI - PubMed

[6] Anderson TJC, Haubold B, Williams JT, Estrada-Franco JG, Richardson L, Mollinedo R, Bockarie M, Mokili J, Mharakurwa S, French N, Whitworth J, Velez ID, Brockman AH, Nosten F, Ferreira MU, Day KP. 2000. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol Biol Evol 17:1467–1482. doi:10.1093/oxfordjournals.molbev.a026247. - DOI - PubMed

[7] Savini H, Bogreau H, Bertaux L, Bouchiba H, Kraemer P, Parzy D, Garnotel E, Rogier C, Simon F, Pradines B. 2008. First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros. Antimicrob Agents Chemother 52:2283–2284. doi:10.1128/AAC.00282-08. - DOI - PMC - PubMed

[8] Savini H, Bogreau H, Bertaux L, Bouchiba H, Kraemer P, Parzy D, Garnotel E, Rogier C, Simon F, Pradines B. 2008. First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros. Antimicrob Agents Chemother 52:2283–2284. doi:10.1128/AAC.00282-08. - DOI - PMC - PubMed

[9] Javelle E, Madamet M, Gaillard T, Velut G, Surcouf C, Michel R, Garnotel E, Simon F, Pradines B. 2016. Delayed P. falciparum malaria after doxycycline prophylaxis, Central African Republic. Antimicrob Agents Chemother 60:2592–2593. doi:10.1128/AAC.01858-15. - DOI - PMC - PubMed

[10] Javelle E, Madamet M, Gaillard T, Velut G, Surcouf C, Michel R, Garnotel E, Simon F, Pradines B. 2016. Delayed P. falciparum malaria after doxycycline prophylaxis, Central African Republic. Antimicrob Agents Chemother 60:2592–2593. doi:10.1128/AAC.01858-15. - DOI - PMC - PubMed

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Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic

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Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic

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