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Review
. 2018 Feb;71(2):218-223.
doi: 10.1161/HYPERTENSIONAHA.117.10391. Epub 2017 Dec 11.

Aging and Adrenal Aldosterone Production

Affiliations
Review

Aging and Adrenal Aldosterone Production

Kazutaka Nanba et al. Hypertension. 2018 Feb.
No abstract available

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Figures

Figure 1
Figure 1. Adrenal zonation and steroidogenic pathway
A. Adrenal cortex zonation with the primary regulators of steroid production. B. Steroidogenic pathway for the production of aldosterone and cortisol. Aldosterone and cortisol production occur in the zona glomerulosa (ZG) and zona fasciculata (ZF), respectively
Figure 2
Figure 2. Age-related histological changes in human adrenal glands
Continuous CYP11B2 expression in the zona glomerulosa (ZG) is often seen in young adrenal glands, whereas older adrenals have less normal ZG CYP11B2 expression and more APCC. Potential effects that might cause the age-associated increase in CYP11B2-positive APCC include genomic, epigenetic events or environmental factors.

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