Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Jan;29(1):9-12.
doi: 10.1681/ASN.2017111183. Epub 2017 Dec 11.

Clusters Not Classifications: Making Sense of Complement-Mediated Kidney Injury

H Terence Cook  1 , Matthew C Pickering  2
Affiliations
Editorial

Clusters Not Classifications: Making Sense of Complement-Mediated Kidney Injury

H Terence Cook et al. J Am Soc Nephrol. 2018 Jan.
No abstract available

Keywords: C3 glomerulopathy; dense deposit disease; glomerulonephritis; membranoproliferative glomerulonephritis (MPGN).

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Concepts of phenotyping in complement-mediated disease have evolved over the last decade. (A) The complex relationship between the pathologic features of MPGN and C3 glomerulopathy. Subgroups of C3 glomerulopathy can be defined by pathologic features (DDD and C3GN) or the presence of a specific genetic defect (CFHR5 nephropathy and a familial C3GN). (B) Classification on the basis of the renal biopsy. Patients are classified on the basis of renal biopsy features. Clinical data (generic and specific; e.g., complement assays) are then interpreted and analyzed within these categories together with outcome and treatment responses. (C) Unsupervised hierarchical clustering is used to discover unknown subgroups within the dataset. Existing biopsy classifications are used to determine which patients to include in the dataset.
See this image and copyright information in PMC

Comment on

References

    1. Fakhouri F, Frémeaux-Bacchi V, Noël LH, Cook HT, Pickering MC: C3 glomerulopathy: A new classification. Nat Rev Nephrol 6: 494–499, 2010 - PubMed
    1. Berger J, Galle P: [Dense deposits within the basal membranes of the kidney. Optical and electron microscopic study]. Presse Med 71: 2351–2354, 1963 - PubMed
    1. Servais A, Frémeaux-Bacchi V, Lequintrec M, Salomon R, Blouin J, Knebelmann B, Grünfeld JP, Lesavre P, Noël LH, Fakhouri F: Primary glomerulonephritis with isolated C3 deposits: A new entity which shares common genetic risk factors with haemolytic uraemic syndrome. J Med Genet 44: 193–199, 2007 - PMC - PubMed
    1. Servais A, Noël LH, Roumenina LT, Le Quintrec M, Ngo S, Dragon-Durey MA, Macher MA, Zuber J, Karras A, Provot F, Moulin B, Grünfeld JP, Niaudet P, Lesavre P, Frémeaux-Bacchi V: Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. Kidney Int 82: 454–464, 2012 - PubMed
    1. Gale DP, de Jorge EG, Cook HT, Martinez-Barricarte R, Hadjisavvas A, McLean AG, Pusey CD, Pierides A, Kyriacou K, Athanasiou Y, Voskarides K, Deltas C, Palmer A, Frémeaux-Bacchi V, de Cordoba SR, Maxwell PH, Pickering MC: Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet 376: 794–801, 2010 - PMC - PubMed

Substances