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Review
. 2017 Nov 1;28(suppl_8):viii13-viii15.
doi: 10.1093/annonc/mdx446.

Acquired chemotherapy resistance in ovarian cancer

E L Christie  1   2 , D D L Bowtell  1   2
Affiliations
Free article
Review

Acquired chemotherapy resistance in ovarian cancer

E L Christie et al. Ann Oncol. .
Free article

Abstract

Most women diagnosed with high-grade serous ovarian cancer (HGSC) develop recurrent disease and chemotherapy resistance, despite initially responding to treatment. The genomic characteristics of HGSC samples collected at initial surgery have been extensively studied. However, due to challenges of sample collection following treatment, much less is known about the molecular features of recurrent disease. Our recent studies have identified mechanisms of acquired resistance and biomarkers in recurrent HGSCs that could lead to improved treatment approaches.

Keywords: ctDNA; heterogeneity; ovarian cancer; platinum-resistant; relapse.

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