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Comment
. 2017 Dec 11;32(6):721-723.
doi: 10.1016/j.ccell.2017.11.013.

Genomic Biomarkers Predicting Response to Selective CDK4/6 Inhibition: Progress in an Elusive Search

Geoffrey I Shapiro  1
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Genomic Biomarkers Predicting Response to Selective CDK4/6 Inhibition: Progress in an Elusive Search

Geoffrey I Shapiro. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Gong et al. have analyzed the sensitivity of 560 cell lines to the selective CDK4/6 inhibitor abemaciclib and have defined cancers with specific genomic "D-cyclin activating features (DCAF)" as particularly vulnerable. These findings will facilitate patient selection as development of this drug class continues.

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