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. 2017 Dec;22(49):17-00048.
doi: 10.2807/1560-7917.ES.2017.22.49.17-00048.

Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014

Anaïs Potron  1   2 , Sandrine Bernabeu  1   3   4   5 , Gaëlle Cuzon  1   3   4   5 , Valérie Pontiès  6 , Hervé Blanchard  7 , Elise Seringe  7 , Thierry Naas  1   3   4   5 , Patrice Nordmann  8   9   10   11 , Laurent Dortet  1   3   4   5
Affiliations

Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014

Anaïs Potron et al. Euro Surveill. 2017 Dec.

Abstract

OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The blaOXA-204 gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle.

Keywords: OXA-48-like; antibiotic resistance; carbapenems; endoscope; nosocomial; outbreak.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Rep-PCR analysis of OXA-204-producing Enterobacteriaceae, France, 2012–14 (n = 21)
Figure 2
Figure 2
Synoptic curve of patients involved in the endoscope-related outbreak caused by OXA-204-producing Enterobacteriaceae, France, 2012–14 (n = 22)
See this image and copyright information in PMC

References

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