Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Feb 15;25(2):128-134.
doi: 10.1016/j.chembiol.2017.11.003. Epub 2017 Dec 7.

The Elements of Translational Chemical Biology

Robert A Copeland  1 , P Ann Boriack-Sjodin  2
Affiliations
Free article
Review

The Elements of Translational Chemical Biology

Robert A Copeland et al. Cell Chem Biol. .
Free article

Abstract

A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these molecules.

Keywords: cellular assays; chemical biology; drug discovery; target validation.

PubMed Disclaimer

MeSH terms

LinkOut - more resources