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Comment
. 2017 Dec 19;114(51):E10856-E10858.
doi: 10.1073/pnas.1716644115. Epub 2017 Dec 12.

No reason to reconsider HIF-2 as an oncogene in neuroblastoma and other cancer forms

Sofie Mohlin  1 , Kristoffer von Stedingk  1 , Alexander Pietras  2 , Sven Påhlman  3
Affiliations
Comment

No reason to reconsider HIF-2 as an oncogene in neuroblastoma and other cancer forms

Sofie Mohlin et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Macrophage marker expression correlates with EPAS1 expression and prognosis in neuroblastoma patients. RNAseq data from the 498-patient cohort described in Westerlund et al. was used for all analyses. (A) Scatter plot of EPAS1 expression versus a z-score–based macrophage signature score. (B and C) Overall survival (B) and event-free survival (C) Kaplan–Meier plots divided based on macrophage signature scores. Pearson’s correlation coefficient, P, and Bonferroni-corrected P values are displayed where applicable.
Fig. 2.
Fig. 2.
Neuronal differentiation markers are unaltered by AZA+RA treatment. RNAseq data published by Westerlund et al. (GSE100568) on xenograft tumors treated with combinations of RA and AZA were used to examine classic clinical markers of neuronal differentiation in neuroblastoma. Reads per kilobase of transcript per million mapped reads (RPKM) expression values of three clinically used diagnostic neuroblastoma markers of neuronal differentiation (TH, CHGA, and SYP) were displayed according to experimental treatments in three neuroblastoma cell line-derived xenografts (CHP-212, LAN-1, and SK-N-AS; A–C, respectively). ANOVA P values are displayed.
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References

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    1. Bindea G, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39:782–795. - PubMed

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