Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Sep;8(9-10):695-700.
doi: 10.18632/genesandcancer.156.

Alcohol, stem cells and cancer

Shoujun Gu  1 , Bao-Ngoc Nguyen  1 , Shuyun Rao  1 , Shulin Li  2 , Kirti Shetty  3 , Asif Rashid  4 , Vivek Shukla  5 , Chu-Xia Deng  1   6 , Lopa Mishra  1   7 , Bibhuti Mishra  1
Affiliations
Review

Alcohol, stem cells and cancer

Shoujun Gu et al. Genes Cancer. 2017 Sep.

Abstract

Dosage, gender, and genetic susceptibility to the effects of alcohol remained only partially elucidated. In this review, we summarize the current knowledge of the mechanisms underlying the role of alcohol in liver and gastrointestinal cancers. In addition, two recent pathways- DNA repair and TGF-β signaling which provide new insights into alcohol in the regulation of cancers and stem cells are also discussed here.

Keywords: DNA repair; TGF-β; alcohol; cancer; stem cells.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST None.

Figures

Figure 1
Figure 1. Schematic diagram of TGF-β/FA pathway dependent regulation on liver stem cells
Figure 2
Figure 2
A. β2SP−/− mouse embryos display some symptom of human fetal alcohol syndrome, microcephaly (white arrow), anencephaly and anophthalmia; B. Alcoholic hepatitis is induced by alcohol in β2SP+/− mice compared to wild type normal controls. Alcoholic hepatitis-like picture in β2SP mutant mice: effect of alcohol on β2SP+/− mice liver. Mice were treated with alcohol at dose of 30ml/day. I) Masson's Trichrome stain for alcohol treatment group; II) H&E stain for alcohol treatment group.
See this image and copyright information in PMC

References

    1. Zakhari S. Chronic alcohol drinking: Liver and pancreatic cancer? Clin Res Hepatol Gastroenterol. 2015;39(Suppl 1):S86–91. - PubMed
    1. Seitz H.K., Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;7:599–612. - PubMed
    1. Matejcic M., Gunter M.J., Ferrari P. Alcohol Metabolism and Oesophageal Cancer: A Systematic Review of the Evidence. Carcinogenesis. 2017 - PubMed
    1. Mishra L., et al. More rapid elimination of alcohol in women as compared to their male siblings. Alcohol Clin Exp Res. 1989;13:752–4. - PubMed
    1. Sato N., et al. Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res. 2001;25:40S–45S. - PubMed

LinkOut - more resources