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Review
. 2017 Dec 10:4:28.
doi: 10.1186/s40662-017-0094-6. eCollection 2017.

Therapeutic approaches for corneal neovascularization

Sepehr Feizi  1 , Amir A Azari  1 , Sharareh Safapour  1
Affiliations
Review

Therapeutic approaches for corneal neovascularization

Sepehr Feizi et al. Eye Vis (Lond). .

Abstract

Angiogenesis refers to new blood vessels that originate from pre-existing vascular structures. Corneal neovascularization which can lead to compromised visual acuity occurs in a wide variety of corneal pathologies. A large subset of measures has been advocated to prevent and/or treat corneal neovascularization with varying degrees of success. These approaches include topical corticosteroid administration, laser treatment, cautery, and fine needle diathermy. Since the imbalance between proangiogenic agents and antiangiogenic agents primarily mediate the process of corneal neovascularization, recent therapies are intended to disrupt the different steps in the synthesis and actions of proangiogenic factors. These approaches, however, are only partially effective and may lead to several side effects. The aim of this article is to review the most relevant treatments for corneal neovascularization available so far.

Keywords: Angiogenesis; Angiogenic therapies; Corneal neovascularization.

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Conflict of interest statement

Ethics approval and consent to participate

Not Applicable.

Competing interests

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Proangiogenic and antiangiogenic factors that influence neovascularization (for details, see text)
See this image and copyright information in PMC

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