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Review
. 2018 Jan;69(1):58-63.
doi: 10.1007/s00105-017-4094-1.

[Drug therapy of acne inversa]

[Article in German]
S Schneider-Burrus  1   2 , E Arpa  3 , C Kors  4 , T Stavermann  5 , R Sabat  6   7 , G Kokolakis  6   7
Affiliations
Review

[Drug therapy of acne inversa]

[Article in German]
S Schneider-Burrus et al. Hautarzt. 2018 Jan.

Erratum in

  • [Correction to: Drug therapy of acne inversa].
    Schneider-Burrus S, Arpa E, Kors C, Stavermann T, Sabat R, Kokolakis G. Schneider-Burrus S, et al. Hautarzt. 2018 Mar;69(3):224. doi: 10.1007/s00105-018-4149-y. Hautarzt. 2018. PMID: 29497777 German. No abstract available.

Abstract

Acne inversa is a chronic inflammatory destructive skin disease that affects about 1% of the population. The therapy should be personalized and consists of surgical and conservative procedures. Antibiotics are administered either topically or systemically. Combination therapy with clindamycin and rifampicin for 10-12 weeks can be very effective. Furthermore, TNF-α inhibitors show adequate efficacy and can be recommended. Adalimumab is the only approved drug product for systemic treatment of acne inversa. The efficacy of retinoids is controversial. Isotretinoin cannot be recommended for the treatment of acne inversa; however, acitretin has been proven to be more effective. Immune-modulating substances, like dapsone, cyclosporine A, methotrexate, colchicine, or corticosteroids, can be considered; however, the study data are insufficient for recommendation. Hormonal therapies can influence the course of the disease. Antiseptics are applied independent of the stage of disease. Patients should be informed about triggering factors.

Keywords: Antibiotics; Antiseptics; Combination therapy; Hidradenitis suppurativa; Pyodermia fistulans sinifica.

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References

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