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Review
. 2018 Mar;39(2):117-124.
doi: 10.1007/s00292-017-0399-1.

[Notochordal tumors : Benign notochordal tumors and chordomas]

[Article in German]
T F E Barth  1 , A von Witzleben  1 , P Möller  1 , S Scheil-Bertram  2   3
Affiliations
Review

[Notochordal tumors : Benign notochordal tumors and chordomas]

[Article in German]
T F E Barth et al. Pathologe. 2018 Mar.

Abstract

Benign notochordal tumors (BNCT) and chordomas are primary bone tumors of the spine with a predominant localization in the sacrum and clival region followed by the vertebral bodies. Besides the most common variant (NOS [not otherwise specified] with hepatoid or renal carcinoma cell-like differentiation) chordomas with chondroid, and polymorphic to anaplastic morphology are described. An unfavorable variant are pediatric chordomas with a loss of INI-1. BNCT and chordomas are characterized by the following immunohistological profile: vimentin+, cytokeratin+/-, epithelial membrane antigen (EMA)+/-, S100 protein+/-, brachyury+. This profile helps to distinguish these tumors from other lesions such as chondrosarcoma, chordoid meningioma, and metastases of carcinoma.

Keywords: Brachyury; Chordoma; Differential diagnosis; Immunohistochemistry.

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References

    1. Trends Genet. 1994 Aug;10(8):280-6 - PubMed
    1. J Clin Neurosci. 2011 Jan;18(1):96-9 - PubMed
    1. Am J Surg Pathol. 2015 Oct;39(10 ):1305-12 - PubMed
    1. Dev Dyn. 2004 Jan;229(1):201-18 - PubMed
    1. J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):647-9 - PubMed

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