Comparing different nanofat procedures on scars: role of the stromal vascular fraction and its clinical implications

Abstract

Aim: Recently, a new fat grafting technique termed 'nanofat grafting' was proposed which improved tissue repair by the stem cells contained in the stromal vascular fraction (SVF) of nanofat. Here, we reported the clinical outcomes of different nanofat procedures in the treatment of scars in relation with SVF cell yield.

Methods: Three different modified nanofat grafting procedures (supercharged-, evo- and centrifuged-modified nanofat) were compared with the classic nanofat method, and histological analysis was performed to assess skin regeneration. Residual nanofat samples were analyzed to determine SVF immunophenotype and yield from each procedure.

Results: Supercharged-modified nanofat gave the best results in terms of clinical outcome and SVF yield. Histological analysis revealed similar skin regeneration in all treatments.

Conclusion: This work suggested a positive correlation between SVF yield and clinical outcomes in the nanofat treatment of scars.

Keywords: adipose-derived stem cells; clinical outcome; nanofat grafting; scars; skin regeneration; stromal vascular fraction.