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. 2017 Dec;20(12):1318-1323.
doi: 10.22038/IJBMS.2017.9554.

Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract

Saied Goodarzi  1 , Mehdi Nateghpour  2 , Parina Asgharian  3 , Abbas Hadjiakhoondi  1   4 , Narguess Yassa  1   2 , Saeed Tavakoli  4 , Jalal Mirzaei  4 , Leila Farivar  2 , Afsaneh Motevalli Haghi  2 , Zahra Tofighi  1   4
Affiliations

Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract

Saied Goodarzi et al. Iran J Basic Med Sci. 2017 Dec.

Abstract

Objectives: Astrodaucus persicus (Apiaceae) is one of the two species of this genus which grows in different parts of Iran. Roots of this plant were rich in benzodioxoles and used as food additive or salad in Iran and near countries. The aim of present study was evaluation of antimalarial and cytotoxic effects of different fractions of A. persicus fruits and roots extracts.

Materials and methods: Ripe fruits and roots of A. persicus were extracted and fractionated by hexane, chloroform, ethyl acetate and methanol, separately. Antimalarial activities of fractions were performed based on Plasmodium berghei suppressive test in mice model and percentage of parasitemia and suppression were determined for each sample. Cytotoxicity of fruits and roots fractions were investigated against human breast adenocarcinoma (MCF-7), colorectal carcinoma (SW480) and normal (L929) cell lines by MTT assay and IC50 of them were measured.

Results: Hexane fraction of roots extract (RHE) and ethyl acetate fraction of fruits extract (FEA) of A. persicus demonstrated highest parasite inhibition (73.3 and 72.3%, respectively at 500 mg/kg/day) which were significantly different from negative control group (P<0.05). In addition, RHE showed potent anticancer activities against MCF-7 (IC50 of 0.01 µg/ml), SW480 (IC50 of 0.36 µg/ml) and L929 (IC50 of 0.70 µg/ml) cell lines.

Conclusion: According to the results, RHE and FEA fractions of A. persicus could be introduced as excellent choice for antimalarial drug discovery. In addition, cytotoxic activity of RHE was noticeable.

Keywords: Antimalaria; Apiaceae; Astrodaucus persicus; Cytotoxic; MTT assay; Plasmodium berghei.

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